Artrite Idiopática Juvenil

Portuguese recommendations for the use of biological therapies in children and adolescents with Juvenile Idiopathic Arthritis - December 2011 update

Objective: To update the Portuguese recommendations in order to assist the rational and safe prescribing of biological therapies in children and adolescents with Juvenile Idiopathic Arthritis (JIA) as more evidence and experience with these drugs are available.

Methods: The recommendations were formulated by Rheumatologists and Pediatricians, with experience in Pediatric Rheumatology, based on literature evidence and consensus opinion. The evidence was sought through a MEDLINE search. The retrieved results were discussed and a set of recommendations proposed. All propositions were extensively debated and the final recommendations formulated.

Results: A consensus was achieved regarding the eligibility, response criteria, maintenance of biologic therapy, and procedures in case of non-response. Also, specific recommendations concerning safety procedures before and while on biologic therapies were formulated.

Conclusions: Thirteen recommendations for guidance biological therapy in children and adolescents with JIA were developed using both evidence-based and expert consensus. These recommendations will be updated as more evidence becomes available and more biological therapies are licensed.

KEYWORDS

Juvenile Idiopathic Arthritis, Children, Guidelines, Biological therapies, Portugal

Portuguese recommendations for the use of biological therapies in children and adolescents with Juvenile Idiopathic Arthritis - December 2011 update